Drug interactions
Dexamethasone-tobramycin + Montelukast
Severity: Minor
Dexamethasone-tobramycin and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone is a weak to moderate CYP3A4 inducer and may modestly lower montelukast exposure. Montelukast is cleared by several pathways, and the clinical effect is generally small, particularly with local ophthalmic dosing.
What this interaction means in plain words
Dexamethasone-tobramycin and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-tobramycin belongs to Anti Bacterial; Montelukast belongs to Respiratory.
Why it happens
Dexamethasone induces CYP3A4, increasing the metabolism of montelukast.
What to do
No routine adjustment is needed; watch for reduced asthma control if systemic dexamethasone is given for a long time.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Frequently asked questions
Can I take Dexamethasone-tobramycin with Montelukast?
MediHelp rates the interaction as minor. Dexamethasone-tobramycin and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone is a weak to moderate CYP3A4 inducer and may modestly lower montelukast exposure. Montelukast is cleared by several pathways, and the clinical effect is generally small, particularly with local ophthalmic dosing.
How serious is the interaction between Dexamethasone-tobramycin and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for reduced asthma control if systemic dexamethasone is given for a long time.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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