Drug interactions
Dexamethasone-tobramycin + Pentamidine
Severity: Major
Dexamethasone-tobramycin and Pentamidine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic pentamidine is nephrotoxic, and combining it with systemic tobramycin raises the risk of kidney injury. Topical or ophthalmic tobramycin adds little risk.
What this interaction means in plain words
Dexamethasone-tobramycin and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-tobramycin belongs to Anti Bacterial; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive direct nephrotoxicity of both drugs on renal tubular cells.
What to do
With systemic tobramycin, monitor serum creatinine and electrolytes and tobramycin levels, and avoid the combination if alternatives exist.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dexamethasone-tobramycin
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Pentamidine?
MediHelp rates the interaction as major. Dexamethasone-tobramycin and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic pentamidine is nephrotoxic, and combining it with systemic tobramycin raises the risk of kidney injury. Topical or ophthalmic tobramycin adds little risk.
How serious is the interaction between Dexamethasone-tobramycin and Pentamidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic tobramycin, monitor serum creatinine and electrolytes and tobramycin levels, and avoid the combination if alternatives exist.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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