Drug interactions
Dexamethasone-tobramycin + Posaconazole
Severity: Minor
Dexamethasone-tobramycin and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole inhibits CYP3A4 and can raise systemic dexamethasone levels, increasing corticosteroid adverse effects such as adrenal suppression. With topical dexamethasone-tobramycin the effect is unlikely to matter.
What this interaction means in plain words
Dexamethasone-tobramycin and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-tobramycin belongs to Anti Bacterial; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibition of CYP3A4 reduces dexamethasone metabolism.
What to do
No change is needed for topical use. With systemic dexamethasone, monitor for steroid excess and consider dose reduction.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Dexamethasone-tobramycin with Posaconazole?
MediHelp rates the interaction as minor. Dexamethasone-tobramycin and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole inhibits CYP3A4 and can raise systemic dexamethasone levels, increasing corticosteroid adverse effects such as adrenal suppression. With topical dexamethasone-tobramycin the effect is unlikely to matter.
How serious is the interaction between Dexamethasone-tobramycin and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is needed for topical use. With systemic dexamethasone, monitor for steroid excess and consider dose reduction.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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