Drug interactions
Dexchlorpheniramine + Maprotiline
Severity: Moderate
Dexchlorpheniramine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation and have anticholinergic activity, so combined use can increase drowsiness, impaired concentration and anticholinergic effects such as urinary retention, dry mouth and confusion, especially in older adults.
What this interaction means in plain words
Dexchlorpheniramine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexchlorpheniramine belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects via H1 and muscarinic receptor blockade.
What to do
Advise caution with driving and machinery and use the lowest effective doses. Prefer a non-sedating antihistamine where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Dexchlorpheniramine with Maprotiline?
MediHelp rates the interaction as moderate. Dexchlorpheniramine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation and have anticholinergic activity, so combined use can increase drowsiness, impaired concentration and anticholinergic effects such as urinary retention, dry mouth and confusion, especially in older adults.
How serious is the interaction between Dexchlorpheniramine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise caution with driving and machinery and use the lowest effective doses. Prefer a non-sedating antihistamine where possible.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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