Drug interactions
Dexchlorpheniramine + Metaxalone
Severity: Moderate
Dexchlorpheniramine and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexchlorpheniramine is a sedating antihistamine, and metaxalone adds to drowsiness and psychomotor impairment. Anticholinergic effects may also add to confusion in older adults.
What this interaction means in plain words
Dexchlorpheniramine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexchlorpheniramine belongs to Respiratory; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depression.
What to do
Counsel on sedation and avoidance of driving. Consider a non-sedating antihistamine, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Dexchlorpheniramine with Metaxalone?
MediHelp rates the interaction as moderate. Dexchlorpheniramine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexchlorpheniramine is a sedating antihistamine, and metaxalone adds to drowsiness and psychomotor impairment. Anticholinergic effects may also add to confusion in older adults.
How serious is the interaction between Dexchlorpheniramine and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and avoidance of driving. Consider a non-sedating antihistamine, especially in older patients.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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