Drug interactions
Dexchlorpheniramine + Thioridazine
Severity: Moderate
Dexchlorpheniramine and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation and have anticholinergic activity, so combined use can increase drowsiness, impaired psychomotor performance, dry mouth, urinary retention and confusion, especially in older adults.
What this interaction means in plain words
Dexchlorpheniramine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexchlorpheniramine belongs to Respiratory; Thioridazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects through histamine H1 and muscarinic receptor blockade.
What to do
Counsel patients to avoid driving or hazardous tasks and monitor for excessive sedation or anticholinergic toxicity. Reduce the dose or choose a non-sedating antihistamine if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Dexchlorpheniramine with Thioridazine?
MediHelp rates the interaction as moderate. Dexchlorpheniramine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation and have anticholinergic activity, so combined use can increase drowsiness, impaired psychomotor performance, dry mouth, urinary retention and confusion, especially in older adults.
How serious is the interaction between Dexchlorpheniramine and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving or hazardous tasks and monitor for excessive sedation or anticholinergic toxicity. Reduce the dose or choose a non-sedating antihistamine if needed.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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