Drug interactions
Dexchlorpheniramine + Tranylcypromine
Severity: Moderate
Dexchlorpheniramine and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can prolong and intensify the anticholinergic effects of first-generation antihistamines such as dexchlorpheniramine, and CNS depression is additive. Patients may develop marked drowsiness, confusion, urinary retention and tachycardia.
What this interaction means in plain words
Dexchlorpheniramine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexchlorpheniramine belongs to Respiratory; Tranylcypromine belongs to Central Nervous System.
Why it happens
MAO inhibition combined with antihistamine anticholinergic and sedative effects produces additive pharmacodynamic toxicity.
What to do
Prefer a non-sedating second-generation antihistamine. If dexchlorpheniramine is needed, use the lowest dose and monitor for sedation and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Dexchlorpheniramine with Tranylcypromine?
MediHelp rates the interaction as moderate. Dexchlorpheniramine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can prolong and intensify the anticholinergic effects of first-generation antihistamines such as dexchlorpheniramine, and CNS depression is additive. Patients may develop marked drowsiness, confusion, urinary retention and tachycardia.
How serious is the interaction between Dexchlorpheniramine and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-sedating second-generation antihistamine. If dexchlorpheniramine is needed, use the lowest dose and monitor for sedation and anticholinergic effects.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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