Drug interactions
Dexfenfluramine + Lisdexamfetamine
Severity: Major
Dexfenfluramine and Lisdexamfetamine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are anorectic serotonergic or sympathomimetic agents. Combining them may increase blood pressure, heart rate and the risk of serotonin toxicity. Dexfenfluramine has been withdrawn in many markets because of valvular heart disease and pulmonary hypertension.
What this interaction means in plain words
Dexfenfluramine and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive sympathomimetic and serotonin-releasing effects.
What to do
Avoid the combination where possible. If used, monitor blood pressure, heart rate and for serotonin syndrome.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dexfenfluramine with Lisdexamfetamine?
MediHelp rates the interaction as major. Dexfenfluramine and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are anorectic serotonergic or sympathomimetic agents. Combining them may increase blood pressure, heart rate and the risk of serotonin toxicity. Dexfenfluramine has been withdrawn in many markets because of valvular heart disease and pulmonary hypertension.
How serious is the interaction between Dexfenfluramine and Lisdexamfetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor blood pressure, heart rate and for serotonin syndrome.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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