Drug interactions
Dexlansoprazole + Lonafarnib
Severity: Moderate
Dexlansoprazole and Lonafarnib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate and a CYP3A inhibitor. Dexlansoprazole is a weak CYP3A inhibitor and substrate, so modest increases in either drug are possible. The main concern is lonafarnib toxicity, including possible QT effects and gastrointestinal effects.
What this interaction means in plain words
Dexlansoprazole and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexlansoprazole belongs to Gastrointestinal Tract; Lonafarnib belongs to Miscellaneous.
Why it happens
Mutual CYP3A-mediated metabolic inhibition, with weak inhibition of lonafarnib clearance by dexlansoprazole.
What to do
Continue lonafarnib at the starting dose if combined and monitor for palpitations, syncope and gastrointestinal toxicity. Consider an ECG if symptoms arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Dexlansoprazole with Lonafarnib?
MediHelp rates the interaction as moderate. Dexlansoprazole and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A substrate and a CYP3A inhibitor. Dexlansoprazole is a weak CYP3A inhibitor and substrate, so modest increases in either drug are possible. The main concern is lonafarnib toxicity, including possible QT effects and gastrointestinal effects.
How serious is the interaction between Dexlansoprazole and Lonafarnib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue lonafarnib at the starting dose if combined and monitor for palpitations, syncope and gastrointestinal toxicity. Consider an ECG if symptoms arise.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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