Drug interactions
Dexlansoprazole + Methylphenidate
Severity: Moderate
Dexlansoprazole and Methylphenidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acid suppression can alter the pH-dependent release of some extended-release methylphenidate formulations, potentially changing the timing or extent of drug delivery. The clinical effect is variable and usually modest.
What this interaction means in plain words
Dexlansoprazole and Methylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexlansoprazole belongs to Gastrointestinal Tract; Methylphenidate belongs to Central Nervous System.
Why it happens
Raised gastric pH may alter release from pH-dependent extended-release methylphenidate formulations.
What to do
Monitor clinical response to methylphenidate when starting or stopping the PPI, and consider a non-pH-dependent formulation if response becomes erratic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Methylphenidate
- Isocarboxazid + Methylphenidate Contraindicated
- Linezolid + Methylphenidate Contraindicated
- Methylphenidate + Phenelzine Contraindicated
- Methylphenidate + Procarbazine Contraindicated
- Methylphenidate + Rasagiline Contraindicated
- Methylphenidate + Safinamide Contraindicated
Frequently asked questions
Can I take Dexlansoprazole with Methylphenidate?
MediHelp rates the interaction as moderate. Dexlansoprazole and Methylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Acid suppression can alter the pH-dependent release of some extended-release methylphenidate formulations, potentially changing the timing or extent of drug delivery. The clinical effect is variable and usually modest.
How serious is the interaction between Dexlansoprazole and Methylphenidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to methylphenidate when starting or stopping the PPI, and consider a non-pH-dependent formulation if response becomes erratic.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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