Drug interactions
Dexlansoprazole + Tacrolimus
Severity: Moderate
Dexlansoprazole and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexlansoprazole can raise tacrolimus blood concentrations, mainly in patients who are CYP2C19 intermediate or poor metabolizers. Higher exposure increases the risk of nephrotoxicity, neurotoxicity and other tacrolimus adverse effects.
What this interaction means in plain words
Dexlansoprazole and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexlansoprazole belongs to Gastrointestinal Tract; Tacrolimus belongs to Miscellaneous.
Why it happens
Dexlansoprazole inhibits CYP2C19, which contributes to tacrolimus metabolism, reducing tacrolimus clearance.
What to do
Monitor tacrolimus trough concentrations and renal function when starting or stopping dexlansoprazole, and adjust the tacrolimus dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexlansoprazole and Tacrolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Dexlansoprazole with Tacrolimus?
MediHelp rates the interaction as moderate. Dexlansoprazole and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexlansoprazole can raise tacrolimus blood concentrations, mainly in patients who are CYP2C19 intermediate or poor metabolizers. Higher exposure increases the risk of nephrotoxicity, neurotoxicity and other tacrolimus adverse effects.
How serious is the interaction between Dexlansoprazole and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough concentrations and renal function when starting or stopping dexlansoprazole, and adjust the tacrolimus dose accordingly.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
