Drug interactions
Dexlansoprazole + Tazemetostat
Severity: Minor
Dexlansoprazole and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and could slightly reduce dexlansoprazole exposure. Dexlansoprazole is not a meaningful CYP3A4 inhibitor, so a notable increase in tazemetostat exposure is unlikely.
What this interaction means in plain words
Dexlansoprazole and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexlansoprazole belongs to Gastrointestinal Tract; Tazemetostat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction by tazemetostat may modestly increase dexlansoprazole clearance.
What to do
No dose adjustment is usually needed; monitor for adequacy of acid suppression.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Dexlansoprazole with Tazemetostat?
MediHelp rates the interaction as minor. Dexlansoprazole and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak CYP3A4 inducer and could slightly reduce dexlansoprazole exposure. Dexlansoprazole is not a meaningful CYP3A4 inhibitor, so a notable increase in tazemetostat exposure is unlikely.
How serious is the interaction between Dexlansoprazole and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for adequacy of acid suppression.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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