Drug interactions
Dexlansoprazole + Voriconazole
Severity: Minor
Dexlansoprazole and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and CYP2C19, which are involved in dexlansoprazole metabolism, so dexlansoprazole exposure may rise. Dexlansoprazole is generally well tolerated, so the effect is usually modest in practice.
What this interaction means in plain words
Dexlansoprazole and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexlansoprazole belongs to Gastrointestinal Tract; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP2C19 and CYP3A4, reducing dexlansoprazole clearance.
What to do
No routine dose change is needed; watch for increased PPI adverse effects such as headache or diarrhea during long-term co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Dexlansoprazole with Voriconazole?
MediHelp rates the interaction as minor. Dexlansoprazole and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole inhibits CYP3A4 and CYP2C19, which are involved in dexlansoprazole metabolism, so dexlansoprazole exposure may rise. Dexlansoprazole is generally well tolerated, so the effect is usually modest in practice.
How serious is the interaction between Dexlansoprazole and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for increased PPI adverse effects such as headache or diarrhea during long-term co-therapy.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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