Drug interactions
Dexmedetomidine + Doxepin
Severity: Moderate
Dexmedetomidine and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant with antihistaminic and alpha-blocking activity. Combined with dexmedetomidine it can increase sedation and hypotension.
What this interaction means in plain words
Dexmedetomidine and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexmedetomidine belongs to Central Nervous System; Doxepin belongs to Dermatology.
Why it happens
Additive CNS depression and hypotensive effects (H1 and alpha-1 blockade plus alpha-2 agonism).
What to do
Monitor sedation and blood pressure, and reduce the dose of either drug if oversedation or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexmedetomidine
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Dexmedetomidine with Doxepin?
MediHelp rates the interaction as moderate. Dexmedetomidine and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant with antihistaminic and alpha-blocking activity. Combined with dexmedetomidine it can increase sedation and hypotension.
How serious is the interaction between Dexmedetomidine and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, and reduce the dose of either drug if oversedation or hypotension occurs.
What other medicines interact with Dexmedetomidine?
MediHelp also lists interactions of Dexmedetomidine with, for example, Buprenorphine long-acting, Calcium / magnesium / potassium / sodium oxybates, Dextromoramide. The full list is on the Dexmedetomidine page.
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