Drug interactions
Dexmedetomidine + Dutasteride-tamsulosin
Severity: Moderate
Dexmedetomidine and Dutasteride-tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmedetomidine causes dose-related hypotension and bradycardia, which may be additive with tamsulosin's vasodilatory effect. Pharmacokinetic inhibition of CYP2D6 is not clinically established.
What this interaction means in plain words
Dexmedetomidine and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexmedetomidine belongs to Central Nervous System; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Additive hypotensive effects from central sympatholysis and alpha-1 blockade.
What to do
Monitor blood pressure and heart rate during dexmedetomidine infusion in patients taking tamsulosin. Be prepared to adjust the infusion rate and treat hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Dexmedetomidine with Dutasteride-tamsulosin?
MediHelp rates the interaction as moderate. Dexmedetomidine and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexmedetomidine causes dose-related hypotension and bradycardia, which may be additive with tamsulosin's vasodilatory effect. Pharmacokinetic inhibition of CYP2D6 is not clinically established.
How serious is the interaction between Dexmedetomidine and Dutasteride-tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during dexmedetomidine infusion in patients taking tamsulosin. Be prepared to adjust the infusion rate and treat hypotension.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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