Drug interactions
Dexmedetomidine + Maprotiline
Severity: Moderate
Dexmedetomidine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmedetomidine is a sedative alpha-2 agonist, and maprotiline is a sedating antidepressant, so combined use can deepen sedation. Hypotension and bradycardia from dexmedetomidine may also be exaggerated by the orthostatic effects of maprotiline.
What this interaction means in plain words
Dexmedetomidine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexmedetomidine belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression and additive hypotensive effects.
What to do
Titrate dexmedetomidine to the lowest effective dose and monitor sedation level, heart rate and blood pressure. Anesthesia teams should be told the patient is taking maprotiline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Dexmedetomidine with Maprotiline?
MediHelp rates the interaction as moderate. Dexmedetomidine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexmedetomidine is a sedative alpha-2 agonist, and maprotiline is a sedating antidepressant, so combined use can deepen sedation. Hypotension and bradycardia from dexmedetomidine may also be exaggerated by the orthostatic effects of maprotiline.
How serious is the interaction between Dexmedetomidine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate dexmedetomidine to the lowest effective dose and monitor sedation level, heart rate and blood pressure. Anesthesia teams should be told the patient is taking maprotiline.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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