Drug interactions
Dexmedetomidine + Oliceridine
Severity: Major
Dexmedetomidine and Oliceridine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Co-administration may produce profound sedation, respiratory depression, hypotension and bradycardia. The opioid and alpha-2 agonist effects are additive.
What this interaction means in plain words
Dexmedetomidine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexmedetomidine belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression via mu-opioid agonism and alpha-2 adrenergic sedation.
What to do
Use the lowest effective doses, titrate carefully, and monitor respiratory rate, oxygen saturation, sedation and hemodynamics continuously.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dexmedetomidine
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Dexmedetomidine with Oliceridine?
MediHelp rates the interaction as major. Dexmedetomidine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Co-administration may produce profound sedation, respiratory depression, hypotension and bradycardia. The opioid and alpha-2 agonist effects are additive.
How serious is the interaction between Dexmedetomidine and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses, titrate carefully, and monitor respiratory rate, oxygen saturation, sedation and hemodynamics continuously.
What other medicines interact with Dexmedetomidine?
MediHelp also lists interactions of Dexmedetomidine with, for example, Buprenorphine long-acting, Calcium / magnesium / potassium / sodium oxybates, Dextromoramide. The full list is on the Dexmedetomidine page.
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