Drug interactions
Dexmedetomidine + Oxymorphone
Severity: Moderate
Dexmedetomidine and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmedetomidine is a sedative alpha-2 agonist that enhances the sedative and analgesic effects of opioids. Combined use can cause deeper sedation, bradycardia and hypotension.
What this interaction means in plain words
Dexmedetomidine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexmedetomidine belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression and hemodynamic effects through alpha-2 agonism and opioid agonism.
What to do
Reduce the dose of one or both agents as needed and monitor sedation level, heart rate and blood pressure continuously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Dexmedetomidine with Oxymorphone?
MediHelp rates the interaction as moderate. Dexmedetomidine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexmedetomidine is a sedative alpha-2 agonist that enhances the sedative and analgesic effects of opioids. Combined use can cause deeper sedation, bradycardia and hypotension.
How serious is the interaction between Dexmedetomidine and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the dose of one or both agents as needed and monitor sedation level, heart rate and blood pressure continuously.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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