Drug interactions
Dexmedetomidine + Tamsulosin
Severity: Minor
Dexmedetomidine and Tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmedetomidine lowers blood pressure and heart rate through central alpha-2 agonism, which may add to the hypotensive effect of tamsulosin. A CYP2D6 interaction is unlikely to be meaningful.
What this interaction means in plain words
Dexmedetomidine and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexmedetomidine belongs to Central Nervous System; Tamsulosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic hypotension; pharmacokinetic effect is unestablished.
What to do
Monitor blood pressure and heart rate during dexmedetomidine infusion in patients taking tamsulosin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Dexmedetomidine with Tamsulosin?
MediHelp rates the interaction as minor. Dexmedetomidine and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexmedetomidine lowers blood pressure and heart rate through central alpha-2 agonism, which may add to the hypotensive effect of tamsulosin. A CYP2D6 interaction is unlikely to be meaningful.
How serious is the interaction between Dexmedetomidine and Tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during dexmedetomidine infusion in patients taking tamsulosin.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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