Drug interactions
Dexmedetomidine + Ziprasidone
Severity: Moderate
Dexmedetomidine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmedetomidine is a sedative alpha-2 agonist and ziprasidone is also sedating, so together they can deepen sedation. Hypotension and bradycardia from dexmedetomidine may be amplified by the alpha-blocking effects of ziprasidone.
What this interaction means in plain words
Dexmedetomidine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexmedetomidine belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and additive hypotensive effects through alpha-adrenergic pathways.
What to do
Titrate dexmedetomidine to the desired sedation level and monitor blood pressure, heart rate and level of consciousness. Lower the dexmedetomidine dose if excessive sedation or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexmedetomidine and Ziprasidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Dexmedetomidine with Ziprasidone?
MediHelp rates the interaction as moderate. Dexmedetomidine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexmedetomidine is a sedative alpha-2 agonist and ziprasidone is also sedating, so together they can deepen sedation. Hypotension and bradycardia from dexmedetomidine may be amplified by the alpha-blocking effects of ziprasidone.
How serious is the interaction between Dexmedetomidine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate dexmedetomidine to the desired sedation level and monitor blood pressure, heart rate and level of consciousness. Lower the dexmedetomidine dose if excessive sedation or hypotension occurs.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
