Drug interactions
Dextroamphetamine + Sodium zirconium cyclosilicate
Severity: Minor
Dextroamphetamine and Sodium zirconium cyclosilicate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium zirconium cyclosilicate may transiently raise gastric pH, potentially affecting dissolution of pH-dependent oral drugs such as modified-release dextroamphetamine. The clinical effect is uncertain.
What this interaction means in plain words
Dextroamphetamine and Sodium zirconium cyclosilicate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextroamphetamine belongs to Central Nervous System; Sodium zirconium cyclosilicate belongs to Miscellaneous.
Why it happens
Increased gastric pH may alter dissolution and release of pH-dependent oral formulations.
What to do
Separate oral dextroamphetamine from sodium zirconium cyclosilicate by at least 2 hours and monitor clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Sodium zirconium cyclosilicate
- Cefditoren + Sodium zirconium cyclosilicate Moderate
- Cefpodoxime + Sodium zirconium cyclosilicate Moderate
- Cefuroxime + Sodium zirconium cyclosilicate Moderate
- Crizotinib + Sodium zirconium cyclosilicate Moderate
- Dasatinib + Sodium zirconium cyclosilicate Moderate
- Erlotinib + Sodium zirconium cyclosilicate Moderate
Frequently asked questions
Can I take Dextroamphetamine with Sodium zirconium cyclosilicate?
MediHelp rates the interaction as minor. Dextroamphetamine and Sodium zirconium cyclosilicate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sodium zirconium cyclosilicate may transiently raise gastric pH, potentially affecting dissolution of pH-dependent oral drugs such as modified-release dextroamphetamine. The clinical effect is uncertain.
How serious is the interaction between Dextroamphetamine and Sodium zirconium cyclosilicate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral dextroamphetamine from sodium zirconium cyclosilicate by at least 2 hours and monitor clinical response.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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