Drug interactions
Cefuroxime + Sodium zirconium cyclosilicate
Severity: Moderate
Cefuroxime and Sodium zirconium cyclosilicate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium zirconium cyclosilicate can raise gastric pH, and oral cefuroxime axetil absorption depends on gastric acidity. Higher pH may lower cefuroxime exposure and reduce antibiotic efficacy.
What this interaction means in plain words
Cefuroxime and Sodium zirconium cyclosilicate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefuroxime belongs to Anti Bacterial; Sodium zirconium cyclosilicate belongs to Miscellaneous.
Why it happens
Increased gastric pH reduces dissolution and absorption of oral cefuroxime axetil.
What to do
Give oral cefuroxime at least 2 hours before or after sodium zirconium cyclosilicate. Monitor clinical response to the antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefuroxime
- Aluminum hydroxide + Cefuroxime Moderate
- Amikacin + Cefuroxime Moderate
- Bcg vaccine live + Cefuroxime Moderate
- Calcium carbonate + Cefuroxime Moderate
- Calcium + Cefuroxime Moderate
- Cefuroxime + Cholera vaccine Moderate
Other interactions of Sodium zirconium cyclosilicate
- Cefditoren + Sodium zirconium cyclosilicate Moderate
- Cefpodoxime + Sodium zirconium cyclosilicate Moderate
- Crizotinib + Sodium zirconium cyclosilicate Moderate
- Dasatinib + Sodium zirconium cyclosilicate Moderate
- Erlotinib + Sodium zirconium cyclosilicate Moderate
- Itraconazole + Sodium zirconium cyclosilicate Moderate
Frequently asked questions
Can I take Cefuroxime with Sodium zirconium cyclosilicate?
MediHelp rates the interaction as moderate. Cefuroxime and Sodium zirconium cyclosilicate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium zirconium cyclosilicate can raise gastric pH, and oral cefuroxime axetil absorption depends on gastric acidity. Higher pH may lower cefuroxime exposure and reduce antibiotic efficacy.
How serious is the interaction between Cefuroxime and Sodium zirconium cyclosilicate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral cefuroxime at least 2 hours before or after sodium zirconium cyclosilicate. Monitor clinical response to the antibiotic.
What other medicines interact with Cefuroxime?
MediHelp also lists interactions of Cefuroxime with, for example, Aluminum hydroxide, Amikacin, Bcg vaccine live. The full list is on the Cefuroxime page.
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