Drug interactions
Crizotinib + Sodium zirconium cyclosilicate
Severity: Moderate
Crizotinib and Sodium zirconium cyclosilicate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium zirconium cyclosilicate transiently raises gastric pH, and crizotinib solubility is pH-dependent, so absorption could fall. The clinical effect is uncertain but could reduce crizotinib efficacy.
What this interaction means in plain words
Crizotinib and Sodium zirconium cyclosilicate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Sodium zirconium cyclosilicate belongs to Miscellaneous.
Why it happens
Increased gastric pH may reduce dissolution and absorption of crizotinib.
What to do
Give crizotinib at least 2 hours before or after sodium zirconium cyclosilicate and monitor treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Sodium zirconium cyclosilicate
- Cefditoren + Sodium zirconium cyclosilicate Moderate
- Cefpodoxime + Sodium zirconium cyclosilicate Moderate
- Cefuroxime + Sodium zirconium cyclosilicate Moderate
- Dasatinib + Sodium zirconium cyclosilicate Moderate
- Erlotinib + Sodium zirconium cyclosilicate Moderate
- Itraconazole + Sodium zirconium cyclosilicate Moderate
Frequently asked questions
Can I take Crizotinib with Sodium zirconium cyclosilicate?
MediHelp rates the interaction as moderate. Crizotinib and Sodium zirconium cyclosilicate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium zirconium cyclosilicate transiently raises gastric pH, and crizotinib solubility is pH-dependent, so absorption could fall. The clinical effect is uncertain but could reduce crizotinib efficacy.
How serious is the interaction between Crizotinib and Sodium zirconium cyclosilicate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give crizotinib at least 2 hours before or after sodium zirconium cyclosilicate and monitor treatment response.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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