Drug interactions
Dasatinib + Sodium zirconium cyclosilicate
Severity: Moderate
Dasatinib and Sodium zirconium cyclosilicate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib absorption depends on acidic gastric pH, and sodium zirconium cyclosilicate can raise gastric pH. Dasatinib exposure may fall, risking reduced antileukemic efficacy.
What this interaction means in plain words
Dasatinib and Sodium zirconium cyclosilicate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Sodium zirconium cyclosilicate belongs to Miscellaneous.
Why it happens
Increased gastric pH reduces dasatinib solubility and absorption.
What to do
Separate dasatinib from sodium zirconium cyclosilicate by at least 2 hours. Monitor hematologic and molecular response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Sodium zirconium cyclosilicate
- Cefditoren + Sodium zirconium cyclosilicate Moderate
- Cefpodoxime + Sodium zirconium cyclosilicate Moderate
- Cefuroxime + Sodium zirconium cyclosilicate Moderate
- Crizotinib + Sodium zirconium cyclosilicate Moderate
- Erlotinib + Sodium zirconium cyclosilicate Moderate
- Itraconazole + Sodium zirconium cyclosilicate Moderate
Frequently asked questions
Can I take Dasatinib with Sodium zirconium cyclosilicate?
MediHelp rates the interaction as moderate. Dasatinib and Sodium zirconium cyclosilicate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib absorption depends on acidic gastric pH, and sodium zirconium cyclosilicate can raise gastric pH. Dasatinib exposure may fall, risking reduced antileukemic efficacy.
How serious is the interaction between Dasatinib and Sodium zirconium cyclosilicate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate dasatinib from sodium zirconium cyclosilicate by at least 2 hours. Monitor hematologic and molecular response.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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