Drug interactions
Dextroamphetamine transdermal + Vilazodone
Severity: Moderate
Dextroamphetamine transdermal and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs increase synaptic serotonin, and amphetamines can add to the serotonergic effect of vilazodone. This raises the risk of serotonin syndrome, with agitation, tremor, hyperthermia, diarrhea and autonomic instability, particularly when starting treatment or raising doses.
What this interaction means in plain words
Dextroamphetamine transdermal and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity from vilazodone (SSRI and 5-HT1A partial agonist) and amphetamine-induced serotonin release.
What to do
Start with low doses, titrate slowly and watch for signs of serotonin syndrome, especially after dose changes. If it develops, stop the amphetamine and the other serotonergic drug and give supportive care.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Dextroamphetamine transdermal with Vilazodone?
MediHelp rates the interaction as moderate. Dextroamphetamine transdermal and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs increase synaptic serotonin, and amphetamines can add to the serotonergic effect of vilazodone. This raises the risk of serotonin syndrome, with agitation, tremor, hyperthermia, diarrhea and autonomic instability, particularly when starting treatment or raising doses.
How serious is the interaction between Dextroamphetamine transdermal and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses, titrate slowly and watch for signs of serotonin syndrome, especially after dose changes. If it develops, stop the amphetamine and the other serotonergic drug and give supportive care.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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