Drug interactions
Dextromethorphan + Dronedarone
Severity: Moderate
Dextromethorphan and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone is a moderate CYP2D6 inhibitor and can raise dextromethorphan levels. This may increase dextromethorphan-related dizziness, nausea or sedation, particularly at higher doses.
What this interaction means in plain words
Dextromethorphan and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextromethorphan belongs to Respiratory; Dronedarone belongs to Cardiovascular.
Why it happens
Dronedarone inhibits CYP2D6, reducing conversion of dextromethorphan to dextrorphan.
What to do
Use the lowest effective dextromethorphan dose and monitor for CNS adverse effects such as dizziness or confusion; avoid high or repeated doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dextromethorphan with Dronedarone?
MediHelp rates the interaction as moderate. Dextromethorphan and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone is a moderate CYP2D6 inhibitor and can raise dextromethorphan levels. This may increase dextromethorphan-related dizziness, nausea or sedation, particularly at higher doses.
How serious is the interaction between Dextromethorphan and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dextromethorphan dose and monitor for CNS adverse effects such as dizziness or confusion; avoid high or repeated doses.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
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