Drug interactions
Dextromethorphan + Lasmiditan
Severity: Moderate
Dextromethorphan and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic activity, and combined use may increase the risk of serotonin syndrome. Patients may present with agitation, tremor, hyperthermia, tachycardia and neuromuscular excitability.
What this interaction means in plain words
Dextromethorphan and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextromethorphan belongs to Respiratory; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects: lasmiditan is a 5-HT1F agonist while dextromethorphan inhibits serotonin reuptake.
What to do
Counsel patients to report symptoms of serotonin toxicity promptly. Stop treatment if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Frequently asked questions
Can I take Dextromethorphan with Lasmiditan?
MediHelp rates the interaction as moderate. Dextromethorphan and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have serotonergic activity, and combined use may increase the risk of serotonin syndrome. Patients may present with agitation, tremor, hyperthermia, tachycardia and neuromuscular excitability.
How serious is the interaction between Dextromethorphan and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report symptoms of serotonin toxicity promptly. Stop treatment if serotonin syndrome is suspected.
What other medicines interact with Lasmiditan?
MediHelp also lists interactions of Lasmiditan with, for example, Alprazolam, Amiodarone, Amisulpride. The full list is on the Lasmiditan page.
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