Drug interactions
Dextromethorphan + Peginterferon alfa 2b
Severity: Minor
Dextromethorphan and Peginterferon alfa 2b: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa-2b can alter the activity of drug-metabolizing enzymes, and the effect on CYP2D6 is inconsistent. Dextromethorphan exposure may therefore change in an unpredictable direction, although the clinical effect is usually small.
What this interaction means in plain words
Dextromethorphan and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextromethorphan belongs to Respiratory; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Interferon-mediated modulation of CYP2D6 activity; direction and size of effect are not well established.
What to do
No routine adjustment is needed; monitor for altered cough control or dextromethorphan adverse effects if used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Other interactions of Peginterferon alfa 2b
Frequently asked questions
Can I take Dextromethorphan with Peginterferon alfa 2b?
MediHelp rates the interaction as minor. Dextromethorphan and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peginterferon alfa-2b can alter the activity of drug-metabolizing enzymes, and the effect on CYP2D6 is inconsistent. Dextromethorphan exposure may therefore change in an unpredictable direction, although the clinical effect is usually small.
How serious is the interaction between Dextromethorphan and Peginterferon alfa 2b?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for altered cough control or dextromethorphan adverse effects if used regularly.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
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