Drug interactions
Dextromoramide + Lisdexamfetamine
Severity: Moderate
Dextromoramide and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextromoramide is a potent opioid analgesic that causes sedation and respiratory depression, while lisdexamfetamine is a stimulant. The stimulant may mask sedation without protecting against respiratory depression. Net effects are unpredictable.
What this interaction means in plain words
Dextromoramide and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS pharmacodynamic effects, with possible additive serotonergic or cardiovascular effects.
What to do
Monitor respiratory rate and level of sedation, and use the lowest effective opioid dose. Do not rely on perceived alertness as a sign of safety.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextromoramide with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Dextromoramide and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextromoramide is a potent opioid analgesic that causes sedation and respiratory depression, while lisdexamfetamine is a stimulant. The stimulant may mask sedation without protecting against respiratory depression. Net effects are unpredictable.
How serious is the interaction between Dextromoramide and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate and level of sedation, and use the lowest effective opioid dose. Do not rely on perceived alertness as a sign of safety.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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