Drug interactions
DHEA + Dihydroergotamine intranasal
Severity: Moderate
DHEA and Dihydroergotamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DHEA is reported to affect CYP3A4, but evidence is weak. Intranasal dihydroergotamine is partly metabolized by CYP3A4, and raised levels increase risk of peripheral ischemia.
What this interaction means in plain words
DHEA and Dihydroergotamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP3A4 inhibition by DHEA raising dihydroergotamine levels; not well established.
What to do
Advise avoiding DHEA supplements during dihydroergotamine therapy. Monitor for symptoms of peripheral ischemia or vasospasm.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of DHEA
- DHEA + Dihydroergotamine Moderate
- DHEA + Ergotamine Moderate
- DHEA + Pimozide Moderate
- DHEA + Dronedarone Minor
- DHEA + Erythromycin base Minor
- DHEA + Everolimus Minor
Frequently asked questions
Can I take DHEA with Dihydroergotamine intranasal?
MediHelp rates the interaction as moderate. DHEA and Dihydroergotamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. DHEA is reported to affect CYP3A4, but evidence is weak. Intranasal dihydroergotamine is partly metabolized by CYP3A4, and raised levels increase risk of peripheral ischemia.
How serious is the interaction between DHEA and Dihydroergotamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding DHEA supplements during dihydroergotamine therapy. Monitor for symptoms of peripheral ischemia or vasospasm.
What other medicines interact with DHEA?
MediHelp also lists interactions of DHEA with, for example, Dihydroergotamine, Ergotamine, Pimozide. The full list is on the DHEA page.
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