Drug interactions
DHEA + Everolimus
Severity: Minor
DHEA and Everolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DHEA is not a recognised significant CYP3A4 inhibitor, so an increase in everolimus exposure is theoretical. Everolimus has a narrow therapeutic window, so unexpected changes would matter.
What this interaction means in plain words
DHEA and Everolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
DHEA belongs to Gastrointestinal Tract; Everolimus belongs to Oncology.
Why it happens
Possible minor CYP3A4 or P-gp modulation by DHEA; not established.
What to do
Monitor everolimus trough levels if DHEA is started or stopped. Otherwise no change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of DHEA
- DHEA + Dihydroergotamine Moderate
- DHEA + Dihydroergotamine intranasal Moderate
- DHEA + Ergotamine Moderate
- DHEA + Pimozide Moderate
- DHEA + Dronedarone Minor
- DHEA + Erythromycin base Minor
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take DHEA with Everolimus?
MediHelp rates the interaction as minor. DHEA and Everolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. DHEA is not a recognised significant CYP3A4 inhibitor, so an increase in everolimus exposure is theoretical. Everolimus has a narrow therapeutic window, so unexpected changes would matter.
How serious is the interaction between DHEA and Everolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough levels if DHEA is started or stopped. Otherwise no change is needed.
What other medicines interact with DHEA?
MediHelp also lists interactions of DHEA with, for example, Dihydroergotamine, Dihydroergotamine intranasal, Ergotamine. The full list is on the DHEA page.
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