Drug interactions
DHEA + Erythromycin base
Severity: Minor
DHEA and Erythromycin base: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DHEA is a CYP3A4 substrate, and erythromycin inhibits CYP3A4, so DHEA exposure could increase. The legacy direction is doubtful, and the clinical effect is likely small.
What this interaction means in plain words
DHEA and Erythromycin base have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Erythromycin inhibits CYP3A4, which may increase DHEA levels; effect not well characterized.
What to do
No routine adjustment is needed. Monitor for androgenic or hormonal effects if DHEA supplements are used long term with erythromycin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of DHEA
- DHEA + Dihydroergotamine Moderate
- DHEA + Dihydroergotamine intranasal Moderate
- DHEA + Ergotamine Moderate
- DHEA + Pimozide Moderate
- DHEA + Dronedarone Minor
- DHEA + Everolimus Minor
Frequently asked questions
Can I take DHEA with Erythromycin base?
MediHelp rates the interaction as minor. DHEA and Erythromycin base have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. DHEA is a CYP3A4 substrate, and erythromycin inhibits CYP3A4, so DHEA exposure could increase. The legacy direction is doubtful, and the clinical effect is likely small.
How serious is the interaction between DHEA and Erythromycin base?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for androgenic or hormonal effects if DHEA supplements are used long term with erythromycin.
What other medicines interact with DHEA?
MediHelp also lists interactions of DHEA with, for example, Dihydroergotamine, Dihydroergotamine intranasal, Ergotamine. The full list is on the DHEA page.
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