Drug interactions
DHEA + Ergotamine
Severity: Moderate
DHEA and Ergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotamine toxicity from CYP3A4 inhibition is serious, but DHEA is not a recognised CYP3A4 inhibitor, so this interaction is largely theoretical. Any rise in ergotamine exposure would risk vasospasm and ischemia.
What this interaction means in plain words
DHEA and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
DHEA belongs to Gastrointestinal Tract; Ergotamine belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 effect of DHEA on ergotamine metabolism, not well established.
What to do
Counsel the patient to report numbness, coldness or pain in the extremities. Avoid adding further CYP3A4 inhibitors and use the lowest effective ergotamine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of DHEA
- DHEA + Dihydroergotamine Moderate
- DHEA + Dihydroergotamine intranasal Moderate
- DHEA + Pimozide Moderate
- DHEA + Dronedarone Minor
- DHEA + Erythromycin base Minor
- DHEA + Everolimus Minor
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take DHEA with Ergotamine?
MediHelp rates the interaction as moderate. DHEA and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergotamine toxicity from CYP3A4 inhibition is serious, but DHEA is not a recognised CYP3A4 inhibitor, so this interaction is largely theoretical. Any rise in ergotamine exposure would risk vasospasm and ischemia.
How serious is the interaction between DHEA and Ergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report numbness, coldness or pain in the extremities. Avoid adding further CYP3A4 inhibitors and use the lowest effective ergotamine dose.
What other medicines interact with DHEA?
MediHelp also lists interactions of DHEA with, for example, Dihydroergotamine, Dihydroergotamine intranasal, Pimozide. The full list is on the DHEA page.
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