Drug interactions
DHEA + Dihydroergotamine
Severity: Moderate
DHEA and Dihydroergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DHEA is reported to affect CYP3A4, but evidence for a clinically relevant effect is weak. Dihydroergotamine is a CYP3A4 substrate with a risk of ergotism and vasospasm when levels rise.
What this interaction means in plain words
DHEA and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
DHEA belongs to Gastrointestinal Tract; Dihydroergotamine belongs to Central Nervous System.
Why it happens
Possible CYP3A4 inhibition by DHEA raising dihydroergotamine levels; not well established.
What to do
Advise patients to avoid DHEA supplements during dihydroergotamine therapy. Monitor for numbness, coldness of extremities, or ischemic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of DHEA
- DHEA + Dihydroergotamine intranasal Moderate
- DHEA + Ergotamine Moderate
- DHEA + Pimozide Moderate
- DHEA + Dronedarone Minor
- DHEA + Erythromycin base Minor
- DHEA + Everolimus Minor
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take DHEA with Dihydroergotamine?
MediHelp rates the interaction as moderate. DHEA and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. DHEA is reported to affect CYP3A4, but evidence for a clinically relevant effect is weak. Dihydroergotamine is a CYP3A4 substrate with a risk of ergotism and vasospasm when levels rise.
How serious is the interaction between DHEA and Dihydroergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid DHEA supplements during dihydroergotamine therapy. Monitor for numbness, coldness of extremities, or ischemic symptoms.
What other medicines interact with DHEA?
MediHelp also lists interactions of DHEA with, for example, Dihydroergotamine intranasal, Ergotamine, Pimozide. The full list is on the DHEA page.
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