Drug interactions
DHEA + Pimozide
Severity: Moderate
DHEA and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DHEA supplements may modulate CYP3A4 activity and could change pimozide concentrations. Pimozide has a narrow margin and QT prolongation risk increases with exposure.
What this interaction means in plain words
DHEA and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
DHEA belongs to Gastrointestinal Tract; Pimozide belongs to Central Nervous System.
Why it happens
Possible CYP3A4 modulation by DHEA
What to do
Avoid DHEA supplements in patients taking pimozide, or monitor the ECG and clinical response if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of DHEA
- DHEA + Dihydroergotamine Moderate
- DHEA + Dihydroergotamine intranasal Moderate
- DHEA + Ergotamine Moderate
- DHEA + Dronedarone Minor
- DHEA + Erythromycin base Minor
- DHEA + Everolimus Minor
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take DHEA with Pimozide?
MediHelp rates the interaction as moderate. DHEA and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. DHEA supplements may modulate CYP3A4 activity and could change pimozide concentrations. Pimozide has a narrow margin and QT prolongation risk increases with exposure.
How serious is the interaction between DHEA and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid DHEA supplements in patients taking pimozide, or monitor the ECG and clinical response if used.
What other medicines interact with DHEA?
MediHelp also lists interactions of DHEA with, for example, Dihydroergotamine, Dihydroergotamine intranasal, Ergotamine. The full list is on the DHEA page.
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