Drug interactions
DHEA herbal + Dutasteride
Severity: Minor
DHEA herbal and Dutasteride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DHEA is an androgen precursor and its metabolic effect on CYP3A4 is not established. The interaction is mainly pharmacodynamic since dutasteride blocks conversion of testosterone to dihydrotestosterone.
What this interaction means in plain words
DHEA herbal and Dutasteride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacokinetic mechanism is not established; DHEA may provide androgen substrate that partly opposes 5-alpha-reductase inhibition.
What to do
Avoid unneeded DHEA supplementation in patients on dutasteride. Reassess prostate symptoms if use continues.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride
- Dutasteride + Levoketoconazole Moderate
- Dutasteride + Nefazodone Moderate
- Dutasteride + Rifampin Moderate
- Dutasteride + St john's wort Moderate
- Amobarbital + Dutasteride Minor
- Aprepitant + Dutasteride Minor
Frequently asked questions
Can I take DHEA herbal with Dutasteride?
MediHelp rates the interaction as minor. DHEA herbal and Dutasteride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. DHEA is an androgen precursor and its metabolic effect on CYP3A4 is not established. The interaction is mainly pharmacodynamic since dutasteride blocks conversion of testosterone to dihydrotestosterone.
How serious is the interaction between DHEA herbal and Dutasteride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unneeded DHEA supplementation in patients on dutasteride. Reassess prostate symptoms if use continues.
What other medicines interact with Dutasteride?
MediHelp also lists interactions of Dutasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Dutasteride page.
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