Drug interactions
Diamorphine + Lisdexamfetamine
Severity: Moderate
Diamorphine and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diamorphine (heroin) is an opioid causing sedation and respiratory depression, while lisdexamfetamine is a stimulant. Stimulant effects may mask opioid sedation without reversing respiratory depression. Net effects are unpredictable.
What this interaction means in plain words
Diamorphine and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS pharmacodynamic effects, with possible additive cardiovascular effects.
What to do
Monitor respiratory rate, sedation and cardiovascular status. Use the lowest effective opioid dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Diamorphine with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Diamorphine and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diamorphine (heroin) is an opioid causing sedation and respiratory depression, while lisdexamfetamine is a stimulant. Stimulant effects may mask opioid sedation without reversing respiratory depression. Net effects are unpredictable.
How serious is the interaction between Diamorphine and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate, sedation and cardiovascular status. Use the lowest effective opioid dose.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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