Drug interactions
Diamorphine + Propofol
Severity: Major
Diamorphine and Propofol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol and diamorphine (heroin) together cause additive sedation and respiratory depression. Hypotension and apnea are more likely, particularly with rapid injection or in frail patients.
What this interaction means in plain words
Diamorphine and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via GABA-A potentiation by propofol and mu-opioid receptor agonism by diamorphine.
What to do
Titrate propofol to effect using lower doses and monitor respiratory rate, oxygen saturation, capnography and blood pressure. Have airway and ventilatory support available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Propofol
Frequently asked questions
Can I take Diamorphine with Propofol?
MediHelp rates the interaction as major. Diamorphine and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Propofol and diamorphine (heroin) together cause additive sedation and respiratory depression. Hypotension and apnea are more likely, particularly with rapid injection or in frail patients.
How serious is the interaction between Diamorphine and Propofol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect using lower doses and monitor respiratory rate, oxygen saturation, capnography and blood pressure. Have airway and ventilatory support available.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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