Drug interactions
Diazepam + Erythromycin lactobionate
Severity: Moderate
Diazepam and Erythromycin lactobionate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin inhibits CYP3A4 and can reduce clearance of diazepam, prolonging and intensifying its sedative effects. Elderly or critically ill patients are most at risk.
What this interaction means in plain words
Diazepam and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated metabolism of diazepam by erythromycin.
What to do
Monitor sedation and respiratory status and reduce the diazepam dose if needed. Consider an alternative antibiotic such as azithromycin if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Diazepam with Erythromycin lactobionate?
MediHelp rates the interaction as moderate. Diazepam and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin inhibits CYP3A4 and can reduce clearance of diazepam, prolonging and intensifying its sedative effects. Elderly or critically ill patients are most at risk.
How serious is the interaction between Diazepam and Erythromycin lactobionate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status and reduce the diazepam dose if needed. Consider an alternative antibiotic such as azithromycin if appropriate.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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