Drug interactions
Diazepam + Fluconazole
Severity: Moderate
Diazepam and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP3A4 and CYP2C19 and can substantially raise diazepam concentrations. This may cause prolonged sedation and psychomotor impairment.
What this interaction means in plain words
Diazepam and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP2C19 and CYP3A4, reducing diazepam clearance.
What to do
Monitor for oversedation and reduce the diazepam dose; consider lorazepam or oxazepam as alternatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Diazepam with Fluconazole?
MediHelp rates the interaction as moderate. Diazepam and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP3A4 and CYP2C19 and can substantially raise diazepam concentrations. This may cause prolonged sedation and psychomotor impairment.
How serious is the interaction between Diazepam and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and reduce the diazepam dose; consider lorazepam or oxazepam as alternatives.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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