Drug interactions
Diazepam + Idelalisib
Severity: Major
Diazepam and Idelalisib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and can substantially increase diazepam exposure. This may result in prolonged and excessive sedation and respiratory depression.
What this interaction means in plain words
Diazepam and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diazepam belongs to Musculoskeletal; Idelalisib belongs to Oncology.
Why it happens
Strong inhibition of CYP3A4 decreases diazepam clearance.
What to do
Avoid if possible or reduce the diazepam dose and monitor for oversedation and respiratory depression. Consider a benzodiazepine not dependent on CYP3A, such as lorazepam.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Diazepam
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Diazepam with Idelalisib?
MediHelp rates the interaction as major. Diazepam and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor and can substantially increase diazepam exposure. This may result in prolonged and excessive sedation and respiratory depression.
How serious is the interaction between Diazepam and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible or reduce the diazepam dose and monitor for oversedation and respiratory depression. Consider a benzodiazepine not dependent on CYP3A, such as lorazepam.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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