Drug interactions
Diazepam + Lopinavir
Severity: Moderate
Diazepam and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir inhibits CYP3A4 and may raise diazepam levels, increasing sedation and respiratory depression risk. Ritonavir may also induce other pathways, so the net effect varies.
What this interaction means in plain words
Diazepam and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Lopinavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition by ritonavir-boosted lopinavir reduces diazepam clearance.
What to do
Start with lower diazepam doses and monitor sedation. Consider lorazepam as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Diazepam with Lopinavir?
MediHelp rates the interaction as moderate. Diazepam and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir inhibits CYP3A4 and may raise diazepam levels, increasing sedation and respiratory depression risk. Ritonavir may also induce other pathways, so the net effect varies.
How serious is the interaction between Diazepam and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with lower diazepam doses and monitor sedation. Consider lorazepam as an alternative.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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