Drug interactions
diazepam + mirtazapine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Additive CNS depressant effects may increase sedation, psychomotor impairment, and risk of respiratory depression and falls.
Mechanism of action
Pharmacodynamic: GABA-A potentiation by diazepam plus antihistaminic/sedative effects of mirtazapine → enhanced CNS depression.
Clinical management
Avoid concomitant use if possible; otherwise use lowest effective doses, avoid alcohol/other CNS depressants, and monitor for excessive sedation, respiratory depression, confusion, and falls.
Drug reference
References
- Mirtazapine (Remeron) Prescribing Information — FDA Label
- Diazepam (Valium) Prescribing Information — FDA Label
- Mirtazapine: Drug Interactions — Lexicomp
Frequently asked questions
Can I take diazepam with mirtazapine?
The interaction is rated: Moderate. Additive CNS depressant effects may increase sedation, psychomotor impairment, and risk of respiratory depression and falls.
How serious is the interaction between diazepam and mirtazapine?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between diazepam and mirtazapine managed?
Avoid concomitant use if possible; otherwise use lowest effective doses, avoid alcohol/other CNS depressants, and monitor for excessive sedation, respiratory depression, confusion, and falls.
Why do diazepam and mirtazapine interact?
Pharmacodynamic: GABA-A potentiation by diazepam plus antihistaminic/sedative effects of mirtazapine → enhanced CNS depression.
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