Drug interactions
Diazepam + Nevirapine
Severity: Moderate
Diazepam and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and CYP2B6 and may lower diazepam exposure, potentially reducing its effect. The change is usually modest and gradual after nevirapine is started.
What this interaction means in plain words
Diazepam and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces hepatic CYP3A4 and CYP2C19 metabolism of diazepam.
What to do
Monitor for reduced diazepam efficacy and adjust the dose to response. Reassess if nevirapine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Diazepam with Nevirapine?
MediHelp rates the interaction as moderate. Diazepam and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine induces CYP3A4 and CYP2B6 and may lower diazepam exposure, potentially reducing its effect. The change is usually modest and gradual after nevirapine is started.
How serious is the interaction between Diazepam and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced diazepam efficacy and adjust the dose to response. Reassess if nevirapine is stopped.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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