Drug interactions
Diazepam + Risperidone
Severity: Moderate
Diazepam and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use can produce additive sedation, dizziness and impaired psychomotor performance. Orthostatic hypotension and falls may be more frequent, especially in older adults.
What this interaction means in plain words
Diazepam and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation by diazepam and antihistaminic and alpha-1 antagonist effects of risperidone.
What to do
Use the lowest effective doses and monitor for sedation and orthostatic hypotension, particularly after dose changes. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Diazepam with Risperidone?
MediHelp rates the interaction as moderate. Diazepam and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use can produce additive sedation, dizziness and impaired psychomotor performance. Orthostatic hypotension and falls may be more frequent, especially in older adults.
How serious is the interaction between Diazepam and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and orthostatic hypotension, particularly after dose changes. Counsel patients to avoid driving and alcohol.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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