Drug interactions
Diazepam + Stiripentol
Severity: Moderate
Diazepam and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits several CYP enzymes including CYP2C19 and CYP3A4, which can raise diazepam and desmethyldiazepam concentrations. Increased sedation and respiratory depression may occur. Stiripentol is often combined with clobazam or benzodiazepines in epilepsy, so this is commonly encountered.
What this interaction means in plain words
Diazepam and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19 and CYP3A4 by stiripentol reduces diazepam metabolism.
What to do
Monitor for sedation and reduced alertness and reduce the diazepam dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Stiripentol
Frequently asked questions
Can I take Diazepam with Stiripentol?
MediHelp rates the interaction as moderate. Diazepam and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits several CYP enzymes including CYP2C19 and CYP3A4, which can raise diazepam and desmethyldiazepam concentrations. Increased sedation and respiratory depression may occur. Stiripentol is often combined with clobazam or benzodiazepines in epilepsy, so this is commonly encountered.
How serious is the interaction between Diazepam and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and reduced alertness and reduce the diazepam dose if adverse effects appear.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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