Drug interactions
Diazepam + Trazodone
Severity: Moderate
Diazepam and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking trazodone with diazepam can increase sedation, dizziness and psychomotor impairment. Orthostatic hypotension and falls are particular concerns in older adults.
What this interaction means in plain words
Diazepam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation by diazepam and H1, 5-HT2A and alpha-1 blockade by trazodone.
What to do
Use the lowest effective doses and monitor for oversedation and orthostatic hypotension. Advise avoidance of alcohol and driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Diazepam with Trazodone?
MediHelp rates the interaction as moderate. Diazepam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking trazodone with diazepam can increase sedation, dizziness and psychomotor impairment. Orthostatic hypotension and falls are particular concerns in older adults.
How serious is the interaction between Diazepam and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and orthostatic hypotension. Advise avoidance of alcohol and driving until tolerance is established.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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