Drug interactions
Diazepam + Triclabendazole
Severity: Minor
Diazepam and Triclabendazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole and its metabolites may inhibit CYP2C19, which contributes to diazepam metabolism. Diazepam exposure could rise modestly, increasing sedation.
What this interaction means in plain words
Diazepam and Triclabendazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diazepam belongs to Musculoskeletal; Triclabendazole belongs to Anti Parasitic.
Why it happens
Inhibition of CYP2C19 by triclabendazole reduces diazepam clearance.
What to do
Monitor for increased sedation during the short triclabendazole course and reduce the diazepam dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Other interactions of Triclabendazole
Frequently asked questions
Can I take Diazepam with Triclabendazole?
MediHelp rates the interaction as minor. Diazepam and Triclabendazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triclabendazole and its metabolites may inhibit CYP2C19, which contributes to diazepam metabolism. Diazepam exposure could rise modestly, increasing sedation.
How serious is the interaction between Diazepam and Triclabendazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation during the short triclabendazole course and reduce the diazepam dose if needed.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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