Drug interactions
Diazepam intranasal + Enzalutamide
Severity: Moderate
Diazepam intranasal and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide induces CYP3A4 and CYP2C19, the main enzymes that clear diazepam and its active metabolite. Diazepam exposure may fall, reducing its effectiveness for seizure rescue.
What this interaction means in plain words
Diazepam intranasal and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 and CYP2C19 by enzalutamide accelerates diazepam metabolism.
What to do
Monitor for reduced seizure control or anxiolytic effect and consider dose adjustment or an alternative rescue agent. Reassess when enzalutamide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Enzalutamide?
MediHelp rates the interaction as moderate. Diazepam intranasal and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide induces CYP3A4 and CYP2C19, the main enzymes that clear diazepam and its active metabolite. Diazepam exposure may fall, reducing its effectiveness for seizure rescue.
How serious is the interaction between Diazepam intranasal and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced seizure control or anxiolytic effect and consider dose adjustment or an alternative rescue agent. Reassess when enzalutamide is stopped.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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