Drug interactions
Diazepam intranasal + Posaconazole
Severity: Moderate
Diazepam intranasal and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole inhibits CYP3A4, which contributes to diazepam metabolism, so diazepam exposure and duration of effect may increase. This can cause excessive sedation and respiratory depression.
What this interaction means in plain words
Diazepam intranasal and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Posaconazole inhibits CYP3A4-mediated metabolism of diazepam.
What to do
Monitor for sedation and respiratory depression and counsel patients and carers accordingly. Consider fewer repeat doses and avoid other CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Posaconazole?
MediHelp rates the interaction as moderate. Diazepam intranasal and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole inhibits CYP3A4, which contributes to diazepam metabolism, so diazepam exposure and duration of effect may increase. This can cause excessive sedation and respiratory depression.
How serious is the interaction between Diazepam intranasal and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and counsel patients and carers accordingly. Consider fewer repeat doses and avoid other CNS depressants.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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